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None of the change reached significance, likely due to the limited sample size (Supplemental Table S3B)

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Preclinical data also suggest that melatonin, as well as its precursor 1-tryptophan, can reduce IgE and IL-4 levels, preventing the development of AD (107)

It is also plausible that these weaker receptor-ligand interactions have evolved to the host's benefit to avoid receptor overstimulation, which may have certain negative effects

An article cited in Journal of Cancer Science and Therapy indicated that glutathione deficiency leads to increased levels of oxidative stress, which might lead to cancer

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